Publications
	Amplification and demultiplexing in the insulin regulated Akt pathway in adipocytes Shi-Xiong Tan, Yvonne Ng, Christopher C. Meoli, Ansu Kumar, Poh-Sim Khoo, Daniel J. Fazakerley, Jagath R. Junutula, Shireen Vali, David E. James, Jacqueline Stoeckli STAT3 is a critical mediator of the pro-survival effect of Bcl-2-Racl interaction in human cancer cells. Jia Kang, Shireen Vali, Shweta Kapoor, Taher Abbasi, Shazib Pervaiz. Dynamic modeling of ∝-synuclein aggregation in dopaminergic neuronal system indicates points of neuroprotective intervention: experimental validation with implications for Parkinson's therapy. Sultana Z, Paleologou KE, Al-Mansoori KM, Ardah MT, Singh N, Usmani S, Jiao H, Martin FL, Bharath MM, Vali S, El-Agnaf OM. Neuroscience. 2011 Oct 20. [Epub ahead of print] PMID: 22056602 [PubMed - as supplied by publisher] Related citations Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice Shanmugam MK, Rajendran P, Li F, Nema T, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Ho PC, Hui KM, Sethi G. J Mol Med. 2011 Apr 5. [Epub ahead of print] PMID: 21465181 [PubMed - as supplied by publisher] Related citations Celastrol Inhibits Proliferation and Induces Chemosensitization through downregulation of NF-KB and STAT3 Regulated Gene Products in Multiple Myeloma Cells Kannaiyan R, Hay HS, Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Chng WJ, Sethi G. Br J Pharmacol. 2011 Apr 20. doi: 10.1111/j.1476-5381.2011.01449.x. [Epub ahead of print] PMID: 21506956 [PubMed - as supplied by publisher] Related citations Dual epidermal growth factor receptor (EGFR)/insulin-like growth factor-1 receptor (IGF-1R) inhibitor: A novel approach for overcoming resistance in anticancer treatment. Tandon R, Kapoor S, Vali S, Senthil V, Nithya D, Venkataramanan R, Sharma A, Talwadkar A, Ray A, Bhatnagar PK, Dastidar SG. Eur J Pharmacol. 2011 Jun 1. [Epub ahead of print] PMID: 21640718 [PubMed - as supplied by publisher] Related citations Solid Way to go!     pseudopapillary tumor and wnt signaling pathway Sikora SS, Vali S. J Gastroenterol Hepatol. 2011 Feb;26(2):215-7. doi: 10.1111/j.1440-1746.2010.06570.x. No abstract available. PMID: 21261709 [PubMed - in process] Related citations Suppression of Signal Transducer and Activator of Transcription 3 Activation by Butein Inhibits Growth of Human Hepatocellular Carcinoma in vivo. Rajendran P, Ong TH, Chen L, Li F, Shanmugam M, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Hui KM, Sethi G. Clin Cancer Res. 2010 Dec 3. [Epub ahead of print]PMID: 21131551 [PubMed - as supplied by publisher] Related citations Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma. Cirstea D, Hideshima T, Rodig S, Santo L, Pozzi S, Vallet S, Ikeda H, Perrone G, Gorgun G, Patel K, Desai N, Sportelli P, Kapoor S, Vali S, Mukherjee S, Munshi NC, Anderson KC, Raje N. Mol Cancer Ther. 2010 Apr;9(4):963-75. Epub 2010 Apr 6.PMID: 20371718 [PubMed - indexed for MEDLINE] Related citations A computer simulation of progesterone and Cox2 inhibitor treatment for preterm labor. Equils O, Nambiar P, Hobel CJ, Smith R, Simmons CF, Vali S. PLoS One. 2010 Jan 27;5(1):e8502. Erratum in: PLoS One. 2010;5(2) doi: 10.1371/annotation/d3491dea-c206-4660-940e-7fefdcee5761. PMID: 20111699 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations Virtual prototyping study shows increased ATPase activity of Hsp90 to be the key determinant of cancer phenotype. Vali S, Pallavi R, Kapoor S, Tatu U. Syst Synth Biol. 2010 Mar;4(1):25-33. Epub 2009 Oct 24.PMID: 19856130 [PubMed - in process]Free PMC ArticleFree text Related citations Celecoxib inhibits MDR1 expression through COX-2-dependent mechanism in human hepatocellular carcinoma (HepG2) cell line. Roy KR, Reddy GV, Maitreyi L, Agarwal S, Achari C, Vali S, Reddanna P. Cancer Chemother Pharmacol. 2010 Apr;65(5):903-11. Epub 2009 Aug 15.PMID: 19685055 [PubMed - indexed for MEDLINE] Related citations Insights into the Anti-inflammatory Action of the Soluble Epoxide Hydrolase Inhibitor through Systems Biology based in silico Modeling Appraoch. Shireen Vali, Christine M. Hegedus, Chumki Bhattacharjee, Robinson V, Kara Schmelzer, Bora Inceoglu, Bruce Hammock Experimental Biology 2008, ASPET, San Diego, April 8th, 2008 (Abstract 2908 in Epoxide Hydrolases Session) A kinetic platform for in silico modeling of the metabolic dynamics in Escherichia coli Published Date December 2010 , Volume 2010:3 Pages 97 - 110 DOI 10.2147/AABC.S14368 Aditya Barve1, Anvita Gupta2, Suresh M Solapure2, Ansu Kumar1, Vasanthi Ramachandran2, Kothandaraman Seshadri2, Shireen Vali1, Santanu Datta2 1Cellworks Research India Pvt. Ltd, Bangalore, India; 2AstraZeneca, Bangalore, India Advances and Applications in Bioinformatics and Chemistry